Murmur ↑ with Valsalva
A 16-year-old’s systolic murmur gets louder when he bears down. Why?
Source quote · p. 14
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Source · p. 14
“Histologically, myocytes are hypertrophied and arranged in a haphazard, disorganized pattern.”
cardiomyopathy_lecture.pdfp. 14 · exact quote
Hypertrophic cardiomyopathy
The hallmark is ventricular hypertrophy that disproportionately involves the septum. Histologically, myocytes are hypertrophied and arranged in a haphazard, disorganized pattern.
- Misstoday
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cardiomyopathy_lecture.pdfp. 14
Hypertrophic cardiomyopathy
HCM is the most common cause of sudden cardiac death in young athletes. It is usually inherited as a mutation in a sarcomere protein. The hallmark is ventricular hypertrophy that disproportionately involves the septum. Histologically, myocytes are hypertrophied and arranged in a haphazard pattern. Diastolic filling is impaired. Obstruction worsens as preload falls, so the murmur gets louder with Valsalva.
Sudden death in athletes
Asymmetric septal hypertrophy
Myocyte disarray
Murmur ↑ with Valsalva
Asymmetric septal hypertrophy
An echo shows a 2.4 cm septum and a normal free wall. Which disease fits best?
Source quote · p. 14
Myocyte disarray
A 22-year-old athlete collapses at practice. Histology of the septum would show…
Source quote · p. 14
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